Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts

Regulation of poly(ADP-ribose) (PAR) synthesis and turnover is critical to determining cell fate after genotoxic stress. Hyperactivation of PAR synthesis by poly(ADP-ribose) polymerase-1 (PARP-1) occurs when cells deficient in DNA repair are exposed to genotoxic agents; however, the function of this...

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Main Authors: Gassman, Natalie R., Stefanick, Donna F., Kedar, Padmini S., Horton, Julie K., Wilson, Samuel H.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492265/
https://ncbi.nlm.nih.gov/pubmed/23145148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049301
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