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Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase – a template for drug design
Trypanothione reductase is a key enzyme in the trypanothione-based redox metabolism of pathogenic trypanosomes. Since this system is absent in humans, being replaced with glutathione and glutathione reductase, it offers a target for selective inhibition. The rational design of potent inhibitors requ...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491871/ https://ncbi.nlm.nih.gov/pubmed/15102853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M403187200 |
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