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Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle
Muscle wasting is a major cause of morbidity in the elderly. Ku80 is required for DNA double strand repair and is implicated in telomere maintenance. Complete loss-of-function leads to reduced post-natal growth and severe progeria in mice. We examined the role of Ku80 in age-related skeletal muscle...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
WILEY-VCH Verlag
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491824/ https://ncbi.nlm.nih.gov/pubmed/22915554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201101075 |
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