miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity

Bile secretion is essential for whole body sterol homeostasis. Loss-of-function mutations in specific canalicular transporters in the hepatocyte disrupt bile flow and result in cholestasis. We show that two of these transporters, ABCB11 and ATP8B1, are functional targets of miR-33, a micro-RNA that...

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Detalhes bibliográficos
Main Authors: Allen, Ryan M, Marquart, Tyler J, Albert, Carolyn J, Suchy, Frederick J, Wang, David Q-H, Ananthanarayanan, Meenakshisundaram, Ford, David A, Baldán, Ángel
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491822/
https://ncbi.nlm.nih.gov/pubmed/22767443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201228
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