Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)

Transcription activator-like effector nucleases (TALENs) are an approach for directed gene disruption and have been proved to be effective in various animal models. Here, we report that TALENs can induce somatic mutations in Xenopus embryos with reliably high efficiency and that such mutations are h...

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Библиографические подробности
Главные авторы: Lei, Yong, Guo, Xiaogang, Liu, Yun, Cao, Yang, Deng, Yi, Chen, Xiongfeng, Cheng, Christopher H. K., Dawid, Igor B., Chen, Yonglong, Zhao, Hui
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491516/
https://ncbi.nlm.nih.gov/pubmed/23045671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215421109
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