Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells

Patients with Down syndrome (trisomy 21, T21) have hematologic abnormalities throughout life. Newborns frequently exhibit abnormal blood counts and a clonal preleukemia. Human T21 fetal livers contain expanded erythro-megakaryocytic precursors with enhanced proliferative capacity. The impact of T21...

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Detalhes bibliográficos
Main Authors: Chou, Stella T., Byrska-Bishop, Marta, Tober, Joanna M., Yao, Yu, VanDorn, Daniel, Opalinska, Joanna B., Mills, Jason A., Choi, John Kim, Speck, Nancy A., Gadue, Paul, Hardison, Ross C., Nemiroff, Richard L., French, Deborah L., Weiss, Mitchell J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491490/
https://ncbi.nlm.nih.gov/pubmed/23045704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211175109
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