Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome

BACKGROUND: Induction and promotion of liver cancer by exposure to non-genotoxic carcinogens coincides with epigenetic perturbations, including specific changes in DNA methylation. Here we investigate the genome-wide dynamics of 5-hydroxymethylcytosine (5hmC) as a likely intermediate of 5-methylcyto...

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Hlavní autoři: Thomson, John P, Lempiäinen, Harri, Hackett, Jamie A, Nestor, Colm E, Müller, Arne, Bolognani, Federico, Oakeley, Edward J, Schübeler, Dirk, Terranova, Rémi, Reinhardt, Diana, Moggs, Jonathan G, Meehan, Richard R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491421/
https://ncbi.nlm.nih.gov/pubmed/23034186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-10-r93
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