Improving N-Glycan Coverage using HPLC with Electrospray Ionization at Sub-ambient Pressure with Mass Spectrometry

Human serum glycan profiling with mass spectrometry (MS) has been employed to study several disease conditions and is demonstrating promise for e.g. clinical biomarker discovery. However, the low glycan ionization efficiency and the large dynamic range of glycan concentrations in human sera hinder c...

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Autori principali: Marginean, Ioan, Kronewitter, Scott R., Moore, Ronald J., Slysz, Gordon W., Monroe, Matthew E., Anderson, Gordon, Tang, Keqi, Smith, Richard D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491124/
https://ncbi.nlm.nih.gov/pubmed/23025344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac301961u
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