A Heat-Shock Protein Axis Regulates VEGFR2 Proteolysis, Blood Vessel Development and Repair

Vascular endothelial growth factor A (VEGF-A) binds to the VEGFR2 receptor tyrosine kinase, regulating endothelial function, vascular physiology and angiogenesis. However, the mechanism underlying VEGFR2 turnover and degradation in this response is unclear. Here, we tested a role for heat-shock prot...

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Autores principales: Bruns, Alexander F., Yuldasheva, Nadira, Latham, Antony M., Bao, Leyuan, Pellet-Many, Caroline, Frankel, Paul, Stephen, Sam L., Howell, Gareth J., Wheatcroft, Stephen B., Kearney, Mark T., Zachary, Ian C., Ponnambalam, Sreenivasan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491040/
https://ncbi.nlm.nih.gov/pubmed/23139789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048539
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