Knockout of Insulin-Like Growth Factor-1 Receptor Impairs Distal Lung Morphogenesis

BACKGROUND: Insulin-like growth factors (IGF-I and -II) are pleiotropic regulators of somatic growth and development in vertebrate species. Endocrine and paracrine effects of both hormones are mediated by a common IGF type 1 receptor (IGF-1R). Lethal respiratory failure in neonatal IGF-1R knockout m...

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Main Authors: Epaud, Ralph, Aubey, Flore, Xu, Jie, Chaker, Zayna, Clemessy, Maud, Dautin, Alexandre, Ahamed, Karmène, Bonora, Monique, Hoyeau, Nadia, Fléjou, Jean-François, Mailleux, Arnaud, Clement, Annick, Henrion-Caude, Alexandra, Holzenberger, Martin
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491012/
https://ncbi.nlm.nih.gov/pubmed/23139760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048071
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