Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis

BACKGROUND: Optic neuritis is an acute, demyelinating neuropathy of the optic nerve often representing the first appreciable symptom of multiple sclerosis. Wallerian degeneration of irreversibly damaged optic nerve axons leads to death of retinal ganglion cells, which is the cause of permanent visua...

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Detalhes bibliográficos
Main Authors: Brambilla, Roberta, Dvoriantchikova, Galina, Barakat, David, Ivanov, Dmitry, Bethea, John R, Shestopalov, Valery I
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490907/
https://ncbi.nlm.nih.gov/pubmed/22963651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-213
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