Transgenic Inhibition of Astroglial NF-κB Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation()

In the CNS, the transcription factor NF-κB is a key regulator of inflammation and secondary injury processes. Following trauma or disease, the expression of NF-κB-dependent genes is activated, leading to both protective and detrimental effects. In this study, we show that transgenic inactivation of...

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Veröffentlicht in:J Immunol
Hauptverfasser: Brambilla, Roberta, Persaud, Trikaldarshi, Hu, Xianchen, Karmally, Shaffiat, Shestopalov, Valery I., Dvoriantchikova, Galina, Ivanov, Dmitry, Nathanson, Lubov, Barnum, Scott R., Bethea, John R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291126/
https://ncbi.nlm.nih.gov/pubmed/19234157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802954
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