Free fatty acids induce ER stress and block antiviral activity of interferon alpha against hepatitis C virus in cell culture

BACKGROUND: Hepatic steatosis is recognized as a major risk factor for liver disease progression and impaired response to interferon based therapy in chronic hepatitis C (CHC) patients. The mechanism of response to interferon-alpha (IFN-α) therapy under the condition of hepatic steatosis is unexplor...

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Hlavní autoři: Gunduz, Feyza, Aboulnasr, Fatma M, Chandra, Partha K, Hazari, Sidhartha, Poat, Bret, Baker, Darren P, Balart, Luis A, Dash, Srikanta
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490746/
https://ncbi.nlm.nih.gov/pubmed/22863531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-9-143
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