Impaired antiviral activity of interferon alpha against hepatitis C virus 2a in Huh-7 cells with a defective Jak-Stat pathway

BACKGROUND: The sustained virological response to interferon-alpha (IFN-α) in individuals infected with hepatitis C virus (HCV) genotype 1 is only 50%, but is about 80% in patients infected with genotype 2-6 viruses. The molecular mechanisms explaining the differences in IFN-α responsiveness between...

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Detalhes bibliográficos
Main Authors: Hazari, Sidhartha, Chandra, Partha K, Poat, Bret, Datta, Sibnarayan, Garry, Robert F, Foster, Timothy P, Kousoulas, Gus, Wakita, Takaji, Dash, Srikanta
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831880/
https://ncbi.nlm.nih.gov/pubmed/20149251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-7-36
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