Synthesis and Biological Evaluation of Epidithio-, Epitetrathio- and bis-(Methylthio)diketopiperazines. Synthetic Methodology, Enantioselective Total Synthesis of Epicoccin G, 8,8′-epi-ent-Rostratin B, Gliotoxin, Gliotoxin G, Emethallicin E and Haematocin, and Discovery of New Antiviral and Antimalarial Agents

An improved sulfenylation method for the preparation of epidithio-, epitetrathio- and bis-(methylthio)diketopiperazines from diketopiperazines has been developed. Employing NaHMDS and related bases and elemental sulfur or bis[bis(trimethylsilyl)amino]trisulfide (23) in THF, the developed method was...

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Main Authors: Nicolaou, K. C., Lu, Min, Totokotsopoulos, Sotirios, Heretsch, Philipp, Giguère, Denis, Sun, Ya-Ping, Sarlah, David, Nguyen, Thu Han, Wolf, Ian Coulter, Smee, Donald F., Day, Craig W., Bopp, Selina, Winzeler, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490634/
https://ncbi.nlm.nih.gov/pubmed/22978674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja308429f
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