Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants

To further characterize the genetic basis of primary biliary cirrhosis (PBC), we genotyped 2426 PBC patients and 5731 unaffected controls from three independent cohorts using a single nucleotide polymorphism (SNP) array (Immunochip) enriched for autoimmune disease risk loci. Meta-analysis of the gen...

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Main Authors: Juran, Brian D., Hirschfield, Gideon M., Invernizzi, Pietro, Atkinson, Elizabeth J., Li, Yafang, Xie, Gang, Kosoy, Roman, Ransom, Michael, Sun, Ye, Bianchi, Ilaria, Schlicht, Erik M., Lleo, Ana, Coltescu, Catalina, Bernuzzi, Francesca, Podda, Mauro, Lammert, Craig, Shigeta, Russell, Chan, Landon L., Balschun, Tobias, Marconi, Maurizio, Cusi, Daniele, Heathcote, E. Jenny, Mason, Andrew L., Myers, Robert P., Milkiewicz, Piotr, Odin, Joseph A., Luketic, Velimir A., Bacon, Bruce R., Bodenheimer, Henry C., Liakina, Valentina, Vincent, Catherine, Levy, Cynthia, Franke, Andre, Gregersen, Peter K., Bossa, Fabrizio, Gershwin, M. Eric, deAndrade, Mariza, Amos, Christopher I., Lazaridis, Konstantinos N., Seldin, Michael F., Siminovitch, Katherine A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Association Studies Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490520/
https://ncbi.nlm.nih.gov/pubmed/22936693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds359
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