Carriage of a Tumor Necrosis Factor Polymorphism Amplifies the Cytotoxic T-Lymphocyte Antigen 4 Attributed Risk of Primary Biliary Cirrhosis: Evidence for a Gene–Gene Interaction

Common genetic variants significantly influence complex diseases such as primary biliary cirrhosis (PBC). We recently reported an association between PBC and a single nucleotide polymorphism (rs231725) of the immunoreceptor gene cytotoxic T-lymphocyte antigen 4 (CTLA4). We hypothesized that PBC risk...

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Detalhes bibliográficos
Main Authors: Juran, Brian D., Atkinson, Elizabeth J., Larson, Joseph J., Schlicht, Erik M., Liu, Xiangdong, Heathcote, E. Jenny, Hirschfield, Gideon M., Siminovitch, Katherine A., Lazaridis, Konstantinos N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922843/
https://ncbi.nlm.nih.gov/pubmed/20578265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23667
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