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Primary biliary cirrhosis is associated with a genetic variant in the 3’ flanking region of the CTLA4 gene

BACKGROUND AND AIMS: Genetic variation is invoked as a strong component underlying primary biliary cirrhosis (PBC) and other autoimmune disorders. Data suggests that some of this genetic risk is shared, affecting function of the immune mechanisms controlling self tolerance. Cytotoxic T-lymphocyte an...

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Autores principales: Juran, Brian D., Atkinson, Elizabeth J., Schlicht, Erik M., Fridley, Brooke L., Lazaridis, Konstantinos N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613835/
https://ncbi.nlm.nih.gov/pubmed/18778710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.06.077
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