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Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.

Immune responses to several soluble antigens were compared between B6.C-H-2bm12 mutant and wild-type B6 mice by using a lymph node T-cell proliferation assay. B6.C-H-2bm12 mice failed to respond to beef insulin whereas other IA gene-controlled responses, such as response to poly(L-Tyr, L-Glu)--poly(...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lin, C C, Rosenthal, A S, Passmore, H C, Hansen, T H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349048/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7031650/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.10.6406
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