Thiopurine S-methyltransferase alleles, TPMT(*)2, (*)3B and (*)3C, and genotype frequencies in an Indian population

Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds including thiopurine drugs such as 6-mercaptopurine, 6-thioguanine and azathioprine. TPMT activity exhibits genetic variation and shows tri-modal distribution with 89–94% of individual...

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Hauptverfasser: MURUGESAN, RAJU, VAHAB, SAADI ABDUL, PATRA, SATYAJIT, RAO, REKHA, RAO, JYOTHI, RAI, PADMALATHA, GOPINATH, P.M., SATYAMOORTHY, KAPAETTU
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490340/
https://ncbi.nlm.nih.gov/pubmed/23136604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm_00000021
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