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Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning
Brr2p is one of eight RNA helicases involved in pre-mRNA splicing. Detailed understanding of the functions of Brr2p and other spliceosomal helicases has been limited by lack of knowledge of their in vivo substrates. To address this, sites of direct Brr2p–RNA interaction were identified by in vivo UV...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3489999/ https://ncbi.nlm.nih.gov/pubmed/23124065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.199307.112 |
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