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Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). We recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specific mAb, resulting in increased ADCC against cancer cells.
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3489758/ https://ncbi.nlm.nih.gov/pubmed/23162770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.19974 |
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