A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)

Although T cells can mediate potent antitumor responses, immune tolerance mechanisms often result in the deletion or inactivation of T cells that express T-cell receptors (TCRs) against potentially effective target epitopes. Various approaches have been devised to circumvent this problem. In one app...

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Bibliographic Details
Main Authors: Stone, Jennifer D., Aggen, David H., Schietinger, Andrea, Schreiber, Hans, Kranz, David M.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489742/
https://ncbi.nlm.nih.gov/pubmed/23162754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.20592
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