Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain

BACKGROUND: Sublingual (s.l.) administration of soluble protein antigens, inactivated viruses, or virus-like particles has been shown to induce broad immune responses in mucosal and extra-mucosal tissues. Recombinant replication-defective adenovirus vectors (rADVs) infect mucosa surface and therefor...

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Detalhes bibliográficos
Main Authors: Shim, Byoung-Shik, Stadler, Konrad, Nguyen, Huan Huu, Yun, Cheol-Heui, Kim, Dong Wook, Chang, Jun, Czerkinsky, Cecil, Song, Man Ki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489719/
https://ncbi.nlm.nih.gov/pubmed/22995185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-9-215
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