Development of Safe and Non-Self-Immunogenic Mucosal Adjuvant by Recombinant Fusion of Cholera Toxin A1 Subunit with Protein Transduction Domain

Potential use of cholera toxin (CT) as a mucosal vaccine adjuvant has been documented in a variety of animal models. However, native CT is highly toxic to be used as a mucosal adjuvant in humans. Here, we demonstrate a new approach to generate a mucosal adjuvant by replacing the B subunit of CT with...

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Detalhes bibliográficos
Publicado no:J Immunol Res
Main Authors: Shim, Byoung-Shik, Cheon, In Su, Lee, Eugene, Park, Sung-Moo, Choi, Youngjoo, Jung, Dae-Im, Yang, Eunji, Choi, Jung-ah, Chun, June Young, Kim, Jae-Ouk, Yun, Cheol-Heui, Czerkinsky, Cecil, Song, Man Ki
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863330/
https://ncbi.nlm.nih.gov/pubmed/29707588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/9830701
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