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Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study

BACKGROUND: BRCA1 (breast cancer 1, early onset) missense mutations have been detected in familial breast and ovarian cancers, but the role of these variants in cancer predisposition is often difficult to ascertain. In this work, the molecular mechanisms affected in human cells by two BRCA1 missense...

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Bibliographische Detailangaben
Hauptverfasser: Iofrida, Caterina, Melissari, Erika, Mariotti, Veronica, Guglielmi, Chiara, Guidugli, Lucia, Caligo, Maria Adelaide, Pellegrini, Silvia
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489683/
https://ncbi.nlm.nih.gov/pubmed/22646717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-207
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