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Natural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylation

[Image: see text] A two-step strategy for disaccharide modulation using vancomycin as a model is reported. The strategy relies upon a glycosyltransferase-catalyzed ‘reverse’ reaction to enable the facile attachment of an alkoxyamine-bearing sugar to the vancomycin core. Neoglycosylation of the corre...

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Hlavní autoři: Peltier-Pain, Pauline, Marchillo, Karen, Andes, David R., Thorson, Jon S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489467/
https://ncbi.nlm.nih.gov/pubmed/22984807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol3023374
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