Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

Ribosomal protein (RP) mutations in diseases such as 5q− syndrome both disrupt hematopoiesis and increase the risk of developing hematologic malignancy. However, the mechanism by which RP mutations increase cancer risk has remained an important unanswered question. We show here that monoallelic, ger...

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Autors principals: Rao, Shuyun, Lee, Sang-Yun, Gutierrez, Alejandro, Perrigoue, Jacqueline, Thapa, Roshan J., Tu, Zhigang, Jeffers, John R., Rhodes, Michele, Anderson, Stephen, Oravecz, Tamas, Hunger, Stephen P., Timakhov, Roman A., Zhang, Rugang, Balachandran, Siddharth, Zambetti, Gerard P., Testa, Joseph R., Look, A. Thomas, Wiest, David L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488889/
https://ncbi.nlm.nih.gov/pubmed/22976955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415349
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