Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function

Type 1 IFNs can conditionally activate all of the signal transducers and activators of transcription molecules (STATs), including STAT4. The best-characterized signaling pathways use STAT1, however, and type 1 IFN inhibition of cell proliferation is STAT1 dependent. We report that type 1 IFNs can ba...

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Detalhes bibliográficos
Main Authors: Gil, M. Pilar, Ploquin, Mickaël J. Y., Watford, Wendy T., Lee, Seung-Hwan, Kim, Kwangsin, Wang, Xin, Kanno, Yuka, O'Shea, John J., Biron, Christine A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488885/
https://ncbi.nlm.nih.gov/pubmed/22968462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-428672
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