Inactivation of the lys7 Gene, Encoding Saccharopine Reductase in Penicillium chrysogenum, Leads to Accumulation of the Secondary Metabolite Precursors Piperideine-6-Carboxylic Acid and Pipecolic Acid from α-Aminoadipic Acid

Pipecolic acid serves as a precursor of the biosynthesis of the alkaloids slaframine and swainsonine (an antitumor agent) in some fungi. It is not known whether other fungi are able to synthesize pipecolic acid. Penicillium chrysogenum has a very active α-aminoadipic acid pathway that is used for th...

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Detalles Bibliográficos

Publicado en:	Appl Environ Microbiol
Principais autores:	Naranjo, Leopoldo, Martín de Valmaseda, Eva, Casqueiro, Javier, Ullán, Ricardo V., Lamas-Maceiras, Mónica, Bañuelos, Oscar, Martín, Juan F.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2004
Assuntos:	Physiology and Biotechnology
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348860/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14766586/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.70.2.1031-1039.2004
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