Inactivation of the lys7 Gene, Encoding Saccharopine Reductase in Penicillium chrysogenum, Leads to Accumulation of the Secondary Metabolite Precursors Piperideine-6-Carboxylic Acid and Pipecolic Acid from α-Aminoadipic Acid

Pipecolic acid serves as a precursor of the biosynthesis of the alkaloids slaframine and swainsonine (an antitumor agent) in some fungi. It is not known whether other fungi are able to synthesize pipecolic acid. Penicillium chrysogenum has a very active α-aminoadipic acid pathway that is used for th...

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Bibliographic Details
Main Authors: Naranjo, Leopoldo, Martín de Valmaseda, Eva, Casqueiro, Javier, Ullán, Ricardo V., Lamas-Maceiras, Mónica, Bañuelos, Oscar, Martín, Juan F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Physiology and Biotechnology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC348860/
https://ncbi.nlm.nih.gov/pubmed/14766586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.70.2.1031-1039.2004
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