CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances RORγt Recruitment to the IL17A Promoter in Human T Lymphocytes

Th17 lymphocytes play a key role during immune responses against bacteria and fungi and are involved in the pathophysiology of multiple autoimmune disorders. The co-stimulatory molecules SLAMF3 and SLAMF6 have been implicated in the formation of Th17 phenotypes and IL-17A expression. Increased surfa...

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Main Authors: Chatterjee, Madhumouli, Hedrich, Christian M., Rauen, Thomas, Ioannidis, Christina, Terhorst, Cox, Tsokos, George C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488086/
https://ncbi.nlm.nih.gov/pubmed/22989874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415067
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