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Expansion of Protein Farnesyltransferase Specificity Using “Tunable” Active Site Interactions: DEVELOPMENT OF BIOENGINEERED PRENYLATION PATHWAYS

Post-translational modifications play essential roles in regulating protein structure and function. Protein farnesyltransferase (FTase) catalyzes the biologically relevant lipidation of up to several hundred cellular proteins. Site-directed mutagenesis of FTase coupled with peptide selectivity measu...

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Autors principals: Hougland, James L., Gangopadhyay, Soumyashree A., Fierke, Carol A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488079/
https://ncbi.nlm.nih.gov/pubmed/22992747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404954
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