Extracellular Signal-regulated Kinase 2 (ERK2) Mediates Phosphorylation and Inactivation of Nuclear Interaction Partner of Anaplastic Lymphoma Kinase (NIPA) at G(2)/M

NIPA is an F-box-like protein that contributes to the timing of mitotic entry. It targets nuclear cyclin B1 for ubiquitination in interphase, whereas in G(2)/M phase, NIPA is inactivated by phosphorylation to allow for cyclin B1 accumulation, a critical event for proper G(2)/M transition. We recentl...

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Autores principales: Illert, Anna Lena, Zech, Michael, Moll, Cathrin, Albers, Corinna, Kreutmair, Stefanie, Peschel, Christian, Bassermann, Florian, Duyster, Justus
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488070/
https://ncbi.nlm.nih.gov/pubmed/22955283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.373464
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