SPAK Isoforms and OSR1 Regulate Sodium-Chloride Co-transporters in a Nephron-specific Manner

STE20/SPS-1-related proline-alanine-rich protein kinase (SPAK) and oxidative stress-related kinase (OSR1) activate the potassium-dependent sodium-chloride co-transporter, NKCC2, and thiazide-sensitive sodium-chloride cotransporter, NCC, in vitro, and both co-localize with a kinase regulatory molecul...

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Autors principals: Grimm, P. Richard, Taneja, Tarvinder K., Liu, Jie, Coleman, Richard, Chen, Yang-Yi, Delpire, Eric, Wade, James B., Welling, Paul A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488044/
https://ncbi.nlm.nih.gov/pubmed/22977235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402800
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