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The dependence of expression of NF-κB-dependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3′ UTR

BACKGROUND: The NF-κB family plays a prominent role in the innate immune response, cell cycle activation or cell apoptosis. Upon stimulation by pathogen-associated patterns, such as viral RNA a kinase cascade is activated, which strips the NF-κB of its inhibitor IκBα molecule and allows it to transl...

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Main Authors: Iwanaszko, Marta, Brasier, Allan R, Kimmel, Marek
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488004/
https://ncbi.nlm.nih.gov/pubmed/22577947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-182
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