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Human Milk sIgA Molecules Contain Various Combinations of Different Antigen-Binding Sites Resulting in a Multiple Binding Specificity of Antibodies and Enzymatic Activities of Abzymes

In the classic paradigm, immunoglobulins are monospecific molecules that have stable structures and two or more identical antigen-binding sites. However, we show here for the first time that the sIgA pool of human milk contains, depending on the donor, only 35±5% λ-sIgAs, 48±7% κ-sIgAs, and 17±4% of...

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Detalhes bibliográficos
Main Authors: Sedykh, Sergey E., Buneva, Valentina N., Nevinsky, Georgy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487837/
https://ncbi.nlm.nih.gov/pubmed/23133657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048756
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