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Human Milk IgGs Contain Various Combinations of Different Antigen-Binding Sites Resulting in Multiple Variants of their Bispecificity

In the classic paradigm, immunoglobulins represent products of clonal B cell populations, each producing antibodies (Abs) recognizing a single antigen. There is a common belief that IgGs in mammalian biological fluids are monovalent molecules having stable structures and two identical antigen-bindin...

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Autors principals: Sedykh, Sergey E., Buneva, Valentina N., Nevinsky, Georgy A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418227/
https://ncbi.nlm.nih.gov/pubmed/22912765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042942
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