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Conformations of Islet Amyloid Polypeptide Monomers in a Membrane Environment: Implications for Fibril Formation

The amyloid fibrils formed by islet amyloid polypeptide (IAPP) are associated with type II diabetes. One of the proposed mechanisms of the toxicity of IAPP is that it causes membrane damage. The fatal mutation of S20G human IAPP was reported to lead to early onset of type II diabetes and high tenden...

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Bibliografiske detaljer
Main Authors: Duan, Mojie, Fan, Jue, Huo, Shuanghong
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487734/
https://ncbi.nlm.nih.gov/pubmed/23133593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047150
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