Circadian Gating of Epithelial-to-Mesenchymal Transition in Breast Cancer Cells Via Melatonin-Regulation of GSK3β

Disturbed sleep-wake cycle and circadian rhythmicity are associated with cancer, but the underlying mechanisms are unknown. Employing a tissue-isolated human breast xenograft tumor nude rat model, we observed that glycogen synthase kinase 3β (GSK3β), an enzyme critical in metabolism and cell prolife...

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Main Authors: Mao, Lulu, Dauchy, Robert T., Blask, David E., Slakey, Lauren M., Xiang, Shulin, Yuan, Lin, Dauchy, Erin M., Shan, Bin, Brainard, George C., Hanifin, John P., Frasch, Tripp, Duplessis, Tamika T., Hill, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2012
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487627/
https://ncbi.nlm.nih.gov/pubmed/23002080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1071
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