Mice Harboring Gnrhr E90K, a Mutation that Causes Protein Misfolding and Hypogonadotropic Hypogonadism in Humans, Exhibit Testis Size Reduction and Ovulation Failure

GnRH, produced in the hypothalamus, acts on pituitary gonadotropes to stimulate release of the gonadotropins LH and FSH. Reduced responsiveness of gonadotropes to GnRH is a primary cause of hypogonadotropic hypogonadism (HH), a disease characterized by gonadal dysfunction and low blood levels of gon...

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Autores principales: Stewart, M. David, Deng, Jian Ming, Stewart, C. Allison, Mullen, Rachael D., Wang, Ying, Lopez, Suhujey, Serna, M. Katalina, Huang, Cheng-Chiu, Janovick, Jo Ann, Pask, Andrew J., Schwartz, Robert J., Conn, P. Michael, Behringer, Richard R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2012
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487620/
https://ncbi.nlm.nih.gov/pubmed/22918878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1072
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