Mice Harboring Gnrhr E90K, a Mutation that Causes Protein Misfolding and Hypogonadotropic Hypogonadism in Humans, Exhibit Testis Size Reduction and Ovulation Failure

GnRH, produced in the hypothalamus, acts on pituitary gonadotropes to stimulate release of the gonadotropins LH and FSH. Reduced responsiveness of gonadotropes to GnRH is a primary cause of hypogonadotropic hypogonadism (HH), a disease characterized by gonadal dysfunction and low blood levels of gon...

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Detalhes bibliográficos
Main Authors: Stewart, M. David, Deng, Jian Ming, Stewart, C. Allison, Mullen, Rachael D., Wang, Ying, Lopez, Suhujey, Serna, M. Katalina, Huang, Cheng-Chiu, Janovick, Jo Ann, Pask, Andrew J., Schwartz, Robert J., Conn, P. Michael, Behringer, Richard R.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487620/
https://ncbi.nlm.nih.gov/pubmed/22918878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1072
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