Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

Heme-oxygenase 1 is an endoplasmic reticulum-anchored enzyme that breaks down heme into iron, carbon monoxide and biliverdin. Heme is a hydrophobic co-factor in many proteins, including hemoglobin. Free heme is highly cytotoxic and, therefore, both heme synthesis and breakdown are tightly regulated....

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Autores principales: Gottlieb, Yehonatan, Truman, Marianna, Cohen, Lyora A., Leichtmann-Bardoogo, Yael, Meyron-Holtz, Esther G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2012
Materias:
Original Articles and Brief Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487549/
https://ncbi.nlm.nih.gov/pubmed/22419571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.063651
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