Tafazzin Knockdown in Mice Leads to a Developmental Cardiomyopathy With Early Diastolic Dysfunction Preceding Myocardial Noncompaction

BACKGROUND: Barth syndrome is a rare, multisystem disorder caused by mutations in tafazzin that lead to cardiolipin deficiency and mitochondrial abnormalities. Patients most commonly develop an early-onset cardiomyopathy in infancy or fetal life. METHODS AND RESULTS: Knockdown of tafazzin (TAZKD) in...

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Autores principales: Phoon, Colin K. L., Acehan, Devrim, Schlame, Michael, Stokes, David L., Edelman-Novemsky, Irit, Yu, Dawen, Xu, Yang, Viswanathan, Nitya, Ren, Mindong
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2012
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487377/
https://ncbi.nlm.nih.gov/pubmed/23130124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.111.000455
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