Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

BACKGROUND: Macrophage‐mediated chronic inflammation is mechanistically linked to insulin resistance and atherosclerosis. Although arginase I is considered antiinflammatory, the role of arginase II (Arg‐II) in macrophage function remains elusive. This study characterizes the role of Arg‐II in macrop...

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Detalhes bibliográficos
Main Authors: Ming, Xiu‐Fen, Rajapakse, Angana G., Yepuri, Gautham, Xiong, Yuyan, Carvas, João M., Ruffieux, Jean, Scerri, Isabelle, Wu, Zongsong, Popp, Katja, Li, Jianhui, Sartori, Claudio, Scherrer, Urs, Kwak, Brenda R., Montani, Jean‐Pierre, Yang, Zhihong
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487353/
https://ncbi.nlm.nih.gov/pubmed/23130157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.000992
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