Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

Mammalian target of rapamycin (mTOR)/S6K1 signalling emerges as a critical regulator of aging. Yet, a role of mTOR/S6K1 in aging-associated vascular endothelial dysfunction remains unknown. In this study, we investigated the role of S6K1 in aging-associated endothelial dysfunction and effects of the...

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Bibliografiska uppgifter
Huvudupphovsmän: Rajapakse, Angana G., Yepuri, Gautham, Carvas, João M., Stein, Sokrates, Matter, Christian M., Scerri, Isabelle, Ruffieux, Jean, Montani, Jean-Pierre, Ming, Xiu-Fen, Yang, Zhihong
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081344/
https://ncbi.nlm.nih.gov/pubmed/21544240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019237
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