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Construction of the Octose 8-Phosphate Intermediate in Lincomycin A Biosynthesis: Characterization of the Reactions Catalyzed by LmbR and LmbN
Lincomycin A is a potent antimicrobial agent noted for its unusual C1 methylmercapto-substituted eight-carbon sugar. Despite its long clinical history for the treatment of Grampositive infections, the biosynthesis of the C(8)-sugar, methylthiolincosamide (MTL), is poorly understood. Here, we report...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3486926/ https://ncbi.nlm.nih.gov/pubmed/22989310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja308221z |
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