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In vitro Characterization of LmbK and LmbO: Identification of GDP-D-erythro-α-D-gluco-Octose as a Key Intermediate in Lincomycin A Biosynthesis
Lincomycin A is a clinically useful antibiotic isolated from Streptomyces lincolnensis. It contains an unusual methylmercapto-substituted octose, methylthiolincosamide (MTL). While it has been demonstrated that the C(8) backbone of MTL moiety is derived from D-fructose 6-phosphate and D-ribose 5-pho...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932030/ https://ncbi.nlm.nih.gov/pubmed/24380627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja412194w |
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