Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules

Neisseria meningitis remains a leading cause of sepsis and meningitis, and vaccines are required to prevent infections by this important human pathogen. Factor H binding protein (fHbp) is a key antigen that elicits protective immunity against the meningococcus and recruits the host complement regula...

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Main Authors: Johnson, Steven, Tan, Lionel, van der Veen, Stijn, Caesar, Joseph, Goicoechea De Jorge, Elena, Harding, Rachel J., Bai, Xilian, Exley, Rachel M., Ward, Philip N., Ruivo, Nicola, Trivedi, Kaushali, Cumber, Elspeth, Jones, Rhian, Newham, Luke, Staunton, David, Ufret-Vincenty, Rafael, Borrow, Ray, Pickering, Matthew C., Lea, Susan M., Tang, Christoph M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486911/
https://ncbi.nlm.nih.gov/pubmed/23133374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002981
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