Toxicity Mechanisms of Amphotericin B and Its Neutralization by Conjugation with Arabinogalactan

Amphotericin B (AMB) is an effective antifungal agent. However, its therapeutic use is hampered by its toxicity, mainly due to channel formation across kidney cell membranes and the disruption of postendocytic trafficking. We previously described a safe injectable AMB-arabinogalactan (AG) conjugate...

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Hlavní autoři: Kagan, Sarah, Ickowicz, Diana, Shmuel, Miriam, Altschuler, Yoram, Sionov, Edward, Pitusi, Miriam, Weiss, Aryeh, Farber, Shimon, Domb, Abraham J., Polacheck, Itzhack
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
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Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486601/
https://ncbi.nlm.nih.gov/pubmed/22908154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00612-12
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